The 4b538e50 error prevents you from playing any mode on NBA 2K21 so it is normal that you would want to fix it. Thankfully, the fixes are pretty straightforward so you should be able to get back to dunking on 7-footers with Zion or saucing up the perimeter with the Beard. Let’s get into it.
Check for updates.
On the PlayStation, click the “Options” button on your controller and select “Check for Updates” and on the Xbox, make sure you have auto-updates on. That way, you can be sure that you are running the latest version of the game and do not experience any issues that the devs have already fixed!
Too many accounts.
Another reason this error may have popped up is that 2K only allows for five online accounts to be active on a console at once. There isn’t a workaround for this, and you will have to play the game on one of the five accounts mandatorily.
If you encountered this error while playing the game on Nintendo Switch, simply power off and power up your device. This should fix the problem. Shame it isn’t always this easy!
Suspend firewall software
There is a chance that your third party or Windows antivirus software may be causing the game to misbehave. Temporarily suspend these services and see if that fixes the problem. If you are not comfortable doing this, you can reach out to your security provider and ask them if the service might be interfering with NBA 2K21.
Run as administrator
One of the best fixes for this error is to run the game as an administrator. To do this, right-click on your game launcher and select “Run as an administrator” and fire up the game again. See if this fixes things!
If you face the message “Your MyPlayer account has expired” while doing these steps, simply sign in to your account once again and the problem should be fixed.